# PFASUM60 substitution matrix
# Units = 1/3 Bits
# Entropy H = 0.494095 Bits
# Pfam seed version = 29.0
#
# For further information on the PFASUM substitution model, see 
#
#    PFASUM: A substitution matrix from Pfam structural alignments
#    Frank Keul, Martin Hess, Michael Goesele, Kay Hamacher
#    BMC Bioinformatics, 18(1), 2017
#    http://dx.doi.org/10.1186/s12859-017-1703-z
#
#    Project Website:
#    http://www.cbs.tu-darmstadt.de/PFASUM
#
    A   R   N   D   C   Q   E   G   H   I   L   K   M   F   P   S   T   W   Y   V   B   Z   J   X   *
A   5  -1  -2  -2   0  -1  -1   0  -2  -1  -1  -1  -1  -2  -1   1   0  -3  -3   0  -5  -4  -4 -14  -6
R  -1   7   0  -1  -4   2   0  -2   1  -4  -3   3  -2  -4  -2  -1  -1  -3  -2  -3  -4  -2  -7 -14  -6
N  -2   0   7   2  -3   1   0   0   1  -5  -4   1  -3  -4  -1   1   0  -4  -2  -4   0  -2  -8 -13  -6
D  -2  -1   2   7  -5   1   3  -1   0  -6  -6   0  -4  -6  -1   0  -1  -5  -4  -5   1  -1  -9 -14  -6
C   0  -4  -3  -5  14  -4  -5  -2  -2  -1  -1  -4  -1  -1  -4   0  -1  -2  -1   0  -7  -7  -4 -14  -6
Q  -1   2   1   1  -4   6   2  -2   1  -4  -3   2  -1  -4  -1   0   0  -3  -2  -3  -2   0  -6 -13  -6
E  -1   0   0   3  -5   2   6  -2   0  -5  -4   1  -3  -5  -1   0  -1  -5  -3  -4  -1   0  -8 -14  -6
G   0  -2   0  -1  -2  -2  -2   8  -2  -5  -5  -2  -4  -5  -2   0  -2  -4  -4  -4  -3  -5  -8 -14  -6
H  -2   1   1   0  -2   1   0  -2  10  -4  -3   0  -2  -1  -2  -1  -1  -1   2  -3  -3  -3  -6 -13  -6
I  -1  -4  -5  -6  -1  -4  -5  -5  -4   6   3  -4   2   1  -4  -3  -1  -2  -2   4  -8  -7   0 -14  -6
L  -1  -3  -4  -6  -1  -3  -4  -5  -3   3   5  -4   3   2  -4  -4  -2  -1  -1   1  -8  -7  -1 -14  -6
K  -1   3   1   0  -4   2   1  -2   0  -4  -4   6  -2  -5  -1   0   0  -4  -3  -3  -3  -1  -7 -13  -6
M  -1  -2  -3  -4  -1  -1  -3  -4  -2   2   3  -2   8   1  -4  -2  -1  -1  -1   1  -7  -5  -1 -13  -6
F  -2  -4  -4  -6  -1  -4  -5  -5  -1   1   2  -5   1   8  -4  -3  -3   3   4   0  -8  -8  -2 -14  -6
P  -1  -2  -1  -1  -4  -1  -1  -2  -2  -4  -4  -1  -4  -4  10   0  -1  -4  -4  -3  -4  -4  -7 -14  -6
S   1  -1   1   0   0   0   0   0  -1  -3  -4   0  -2  -3   0   5   2  -4  -3  -2  -2  -3  -7 -13  -6
T   0  -1   0  -1  -1   0  -1  -2  -1  -1  -2   0  -1  -3  -1   2   6  -3  -2   0  -3  -3  -5 -13  -6
W  -3  -3  -4  -5  -2  -3  -5  -4  -1  -2  -1  -4  -1   3  -4  -4  -3  14   3  -2  -8  -7  -4 -14  -6
Y  -3  -2  -2  -4  -1  -2  -3  -4   2  -2  -1  -3  -1   4  -4  -3  -2   3   9  -2  -6  -6  -4 -14  -6
V   0  -3  -4  -5   0  -3  -4  -4  -3   4   1  -3   1   0  -3  -2   0  -2  -2   5  -8  -6  -1 -14  -6
B  -5  -4   0   1  -7  -2  -1  -3  -3  -8  -8  -3  -7  -8  -4  -2  -3  -8  -6  -8   1  -5 -11 -17  -6
Z  -4  -2  -2  -1  -7   0   0  -5  -3  -7  -7  -1  -5  -8  -4  -3  -3  -7  -6  -6  -5   0 -10 -16  -6
J  -4  -7  -8  -9  -4  -6  -8  -8  -6   0  -1  -7  -1  -2  -7  -7  -5  -4  -4  -1 -11 -10   0 -17  -6
X -14 -14 -13 -14 -14 -13 -14 -14 -13 -14 -14 -13 -13 -14 -14 -13 -13 -14 -14 -14 -17 -16 -17 -21  -6
*  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6  -6   1