Metadata-Version: 1.1
Name: prost
Version: 0.7.31
Summary: An application to quantify and annotate miRNA expression.
Home-page: https://github.com/uoregon-postlethwait/prost
Author: Jason Sydes and Peter Batzel
Author-email: sydes@uoregon.edu
License: LICENSE.txt
Description: microRNAs (miRNAs) are an important class of small noncoding RNAs (~22nt) with
        multiple and widespread regulatory roles in many development and disease
        processes. We have created the tool Prost! to explore metazoan miRNA-enriched
        RNA-Seq data. Prost! quantifies and normalizes expression levels (in the form
        of Illumina reads) in several views that are suitable as input into
        differential expression software such as DESeq2. Some key features of Prost!
        include the identification of both candidate mirror-miRNAs and putative 5 ́/3 ́
        mature miRNA arm switching. Of particular interest is the tightly regulated
        post-transcriptional modification of miRNAs via multiple modes of regulation
        during their biogenesis. Such modifications have been found to have important
        consequences on characteristics such as Argonaute loading, target choice, and
        miRNA turnover. Prost! provides valuable quantification across samples of
        several classes of miRNA modifications, for example putative seed shifting,
        seed editing, and untemplated 3 ́ nucleotide additions. 
        
Keywords: bioinformatics microRNA miRNA miR
Platform: UNKNOWN
Classifier: Development Status :: 5 - Production/Stable
Classifier: Intended Audience :: Science/Research
Classifier: Topic :: Scientific/Engineering :: Bio-Informatics
Classifier: License :: Free for non-commercial use
Classifier: Programming Language :: Python :: 2
Classifier: Programming Language :: Python :: 2.7
