Metadata-Version: 2.1
Name: seismic-rna
Version: 0.6.0
Summary: RNA Structure Ensemble Inference via Sequencing, Mutation Identification, and Clustering
Author: Matty Allan, Yves Martin, Scott Grote, Alberic de Lajarte
License: GPL-3.0-only
Project-URL: Homepage, https://github.com/rouskinlab/seismic-rna
Project-URL: Bug Tracker, https://github.com/rouskinlab/seismic-rna/issues
Classifier: Programming Language :: Python :: 3
Classifier: Operating System :: OS Independent
Requires-Python: >=3.10
Description-Content-Type: text/markdown
License-File: LICENSE


# SEISMIC-RNA

RNA Structure Ensemble Inference via Sequencing, Mutation Identification, and
Clustering

![Logo of SEISMIC-RNA](logo.png "SEISMIC-RNA")


## About

SEISMIC-RNA analyzes deep sequencing datasets from RNA mutational profiling
experiments, such as [DMS-MaPseq](https://www.nature.com/articles/nmeth.4057)
and [SHAPE-MaP](https://www.nature.com/articles/nmeth.3029).
This software introduces an optimized implementation of the original algorithm
[DREEM](https://www.nature.com/articles/s41586-020-2253-5) for quantifying and
clustering mutations to infer RNA structural ensembles.


### Contributors

SEISMIC RNA has been developed in [Silvi Rouskin's lab](https://rouskinlab.com)
at Harvard Medical School by the following individuals:

- [Matthew "Matty" Allan](https://github.com/matthewfallan)
- [Yves Martin](https://github.com/yvesmartindestaillades)
- [Scott Grote](https://github.com/heWhosShouldersBlockTheSun)
- [Albéric de Lajarte](https://github.com/AlbericDeLajarte)


## Installation

See `INSTALL.md`.


## Usage

See `USER-MANUAL.md`.


## Development

See `DEV-MANUAL.md`.


## Issues

The [issue page](https://github.com/rouskinlab/seismic-rna/issues) of the GitHub
repository is the official location for reporting bugs and other issues. Before
opening a new issue, please check if a similar issue already exists.
