

:references:

.. [3] **J. Saez-Rodriguez, L. G. Alexopoulos, J. Epperlein, R. Samaga, D. A. Lauffenburger, S. Klamt and P. K. Sorger.**
   *Discrete logic modeling as a means to link protein signaling networks with functional analysis of mammalian signal transduction*
   Molecular Systems Biology, 5:331, 2009




.. note:: the PKN-LiverMSB2009.sif and PKN-LiverMSB2009.csv are slightly
    different from those provided in the journal. See below.

.. topic:: Additional files


    * MD-LiverMSB2009_journal is the original data taken from the journal website. In order to use the provided Network, the header of the file was edited to replace::

        erk12 to ERK
        MEK12 to MEK
        JNK12 to JNK 
        IRS1S to IRS-1S

    * Same modifications for the PKN. In addition, the following reactions are
    * removed from the PKN provided on the journal website::

        STAT6   1   dummy
        CASP37  1   dummy
        BCA 1   dummy








